Table 2

Kinetic parameters in plasma and liver in vivo following intravenous administration of teicoplanin to rats (mean ± S.D.)

Kinetic ParametersMean ± S.D.
Plasma2-a
 A1(μg Eq/ml)57.2  ± 3.6
 A2(μg Eq/ml)2.0  ± 0.3
 A3 (μg Eq/ml)0.035  ± 0.004
 λ1 (h−1)0.28  ± 0.02
 λ2 (h−1)0.042  ± 0.003
 λ3 × 103 (h−1)1.59  ± 0.24
 t 1/2, λ1 (h)2.5  ± 0.1
 t 1/2, λ2 (h)16.3  ± 1.3
 t 1/2, λ3 (h)435  ± 65
 CL (ml/h/kg)2-b 34  ± 1.2
 V SS(l/kg)2-b 1.96  ± 0.35
Liver2-a
 PSu (ml/h)4.4  ± 0.6
 K vivo (ml)22  ± 4
 fuc 0.009  ± 0.001

  • ↵2-a  Composite data taken fromBernareggi et al. (1986) and Zanolo et al. (1991).

  • ↵2-b  Parameters estimated using area and statistical moments (Rowland and Tozer, 1995).

  • See text for definition of parameters.