Clearance estimates calculated from the various in vitro systems
| In Vitro System | Intrinsic Clearance | Hepatic Clearance (Well Stirred Model) |
|---|---|---|
| ml/min in 70 kg bodyweight | ||
| Human liver microsomes | ||
| NADPH Rate of metabolites formed | 31.6 | 31 |
| Human liver microsomes | ||
| UDPGA Vmax/Km | 359 | 287 |
| Human hepatocytes (biopsies) | ||
| Rate of metabolites formed (n = 4) | 248 | 212 |
| Human hepatocytes (liver resections) | ||
| Expt. A Rate of metabolites formed | 917 | 561 |
| Expt. B Rate of metabolites formed | 235 | 202 |
| Tissue slices | ||
| Expt. A Rate of metabolites formed | 71 | 68 |
| Expt. B Rate of metabolites formed | 101 | 94 |