Table 1

Pharmacokinetic parameters of tresperimus after i.v. injection (4 mg/kg) in rat previously treated or not (control) with amine oxidase inhibitors

Inhibitort1/2AUC0–3hRatio of the AUC0–3h
h μg · h · ml−1 % of control
None (control)0.34.1100
Pargyline0.54.8117
Hydralazine0.77.2175
Hydralazine + Pargyline0.511.1270