Table 3

Metabolic profile of M1 and M2 after 3-h incubation at 37°C in rat plasma or in Waymouth medium

Metabolite DetectedMetabolites Incubated
M1M2
In PlasmaIn Waymouth MediumIn PlasmaIn Waymouth Medium
T0T3HT0T3HT0T3HT0T3H
metabolite area/internal standard area
M10.2020.0080.2040.094<LOD<LOD<LOD<LOD
M20.00140.00140.00140.00140.2330.1770.2280.219
M30.0401.1730.0420.5800.0110.0040.003<LOD
M60.0270.1040.00220.00220.0770.3270.00220.0022
  • T0, time zero; T3H, after 3-h incubation period; LOD, limit of detection.