Table 5

Substrate-dependent interactions with CYP3A4 in HLM

CompoundConcentrationActivity
DextromethorphanMidazolamTestosterone
μM % of control ± S.D.
SCH A0.15104  ± 1124  ± 183  ± 16
0.30101  ± 2132  ± 182  ± 7
3.0103  ± 6127  ± 288  ± 8
30.0103  ± 4122  ± 283  ± 9
SCH B0.1583  ± 4167  ± 592  ± 3
0.3072  ± 1152  ± 173  ± 5
3.032.5  ± 581  ± 147  ± 5
30.013  ± 416  ± 022  ± 3