Table 2

Effect of protein concentration on the inhibition of CYP3A4 in the Supersomes assay

CompoundProtein Concentration
mg/ml
0.0360.1000.200
100.240.110.07
221.361.601.03
260.190.120.15
381.251.202.80
390.500.210.26
440.020.040.05
529.709.208.10

IC50 at various protein concentrations (μM).