Quinidine | 10-Hydroxylation ofR-Warfarin | 4′-Hydroxylation ofS-Warfarin | ||
---|---|---|---|---|
Km 5-b | Vmax 5-b | Km 5-b | Vmax 5-b | |
μM | mM | pmol/min/mg | mM | pmol/min/mg |
0 | 0.24 ± 0.04 | 133 ± 12 | 0.12 ± 0.02 | 13 ± 1 |
1 | 0.25 ± 0.07 | 147 ± 17 | 0.13 ± 0.02 | 16 ± 1 |
5 | 0.26 ± 0.05 | 282 ± 22 | 0.14 ± 0.04 | 23 ± 2 |
10 | 0.22 ± 0.04 | 359 ± 27 | 0.13 ± 0.03 | 27 ± 2 |
25 | 0.23 ± 0.04 | 499 ± 34 | 0.12 ± 0.02 | 33 ± 2 |
50 | 0.21 ± 0.03 | 568 ± 31 | 0.11 ± 0.02 | 34 ± 2 |
100 | 0.20 ± 0.03 | 658 ± 39 | 0.13 ± 0.02 | 37 ± 2 |
200 | 0.22 ± 0.04 | 654 ± 44 | 0.13 ± 0.01 | 34 ± 1 |