Table 1

Summary of the apparent kinetic parameters for the hydroxylation of etoricoxib by native human liver microsomes

Liver SampleKm 1-a Vmax 1-a Vmax/Km 1-a
μM nmol/min/mg μl/min/mg
HHM-02531-b 114  ± 2.90.27  ± 0.012.4
HHM-0228164  ± 7.71.2  ± 0.057.3
HHM-0232279  ± 450.78  ± 0.062.9
Mean ± S.D.1-c 186  ± 840.76  ± 0.454.2  ± 2.7
  • 1-a  For each set of microsomes, data were analyzed by nonlinear regression (PCNONLIN). The S.E. of the parameter estimate generated by the PCNONLIN fit is also shown (± S.E.).

  • 1-b  Pool of n = 10 different livers.

  • 1-c  Mean ± S.D. of the three different microsomal preparations.