Table 5

Effect of induction on swine cytochrome P450 activities using liver microsomes

Substrate	P450 Specificity	Induced (Individual Results5-a)		Control (N = 3)
Substrate	P450 Specificity	S.A.	TON5-c	S.A. (Mean 5-a )	TON
Benzo(a)pyrene	1A	3.72, 1.57	2.62, 2.24	0.60 ± 0.10	2.73
ERF	1A	0.30, 0.38	0.21, 0.54	0.07 ± 0.02	0.32
MOC5-b	1A	0.92	0.87	0.18	0.81
MRF5-b	1A	0.06	0.06	0.01	0.04
EtOC	1A, 2A	4.27, 3.12	3.01, 4.46	2.34 ± 1.22	10.64
Aniline	1A, 2E	0.92, 1.08	0.67, 1.54	0.23 ± 0.10	1.04
PNP	1A, 2E	1.11, 0.63	0.78, 0.90	0.31 ± 0.07	1.41
Coumarin	2A	0.95, 0.67	0.67, 0.96	0.12 ± 0.07	0.54
Aminopyrine	2B	4.22, 3.78	2.97, 5.40	1.28 ± 0.45	5.82
MOMC	2B	0.60, 0.40	0.42, 0.57	0.05 ± 0.03	0.22
PRF	2B	0.02, 0.010	0.01, 0.01	0.01 ± 0.00	0.05
EtOMC5-b	2B	0.60	0.57	0.09	0.41
BRF5-b	2B	0.37	0.35	0.02	0.09
Tolbutamide5-b	2C	0.025	0.02	0.013 ± 0.012 (N = 5)	0.06
Testosterone5-b	3A	10.2	9.64	2.52	11.46