Table 2

A comparison of the percentage of the dose metabolized in fresh hepatocyte suspensions, CPHs, GICs, and microsomes

Fresh HCPH2-aGIC2-aMicrosomes2-b

Values expressed as the percentage of parent compound consumed [mean,n = 3 for each system and species, except for fresh dog hepatocytes (n = 1)].

  • Fresh H, fresh hepatocyte suspensions; N.D., not done.

  • 2-a  After 4-h incubation.

  • 2-b  After 2-h incubation.

  • 2-c  After 1-h incubation.