Table 2

A comparison of the percentage of the dose metabolized in fresh hepatocyte suspensions, CPHs, GICs, and microsomes

Fresh HCPH2-aGIC2-aMicrosomes2-b
EMD68843
 Rat292510053
 Dog1222N.D.49
 MonkeyN.D.13N.D.78
 HumanN.D.34452
EMD96785
 Rat1511665
 Dog78N.D.16
 MonkeyN.D.20N.D.27
 HumanN.D.7726
EMD128130
 Rat111459562-c
 Dog3545N.D.722-c
 MonkeyN.D.24N.D.802-c
 HumanN.D.32100442-c

Values expressed as the percentage of parent compound consumed [mean,n = 3 for each system and species, except for fresh dog hepatocytes (n = 1)].

  • Fresh H, fresh hepatocyte suspensions; N.D., not done.

  • 2-a  After 4-h incubation.

  • 2-b  After 2-h incubation.

  • 2-c  After 1-h incubation.