The effect of flavonoids on CYP1A1 mRNA levels in HepG2 cells
| Treatment | HepG2 CYP1A1 mRNA1-a |
|---|---|
| % | |
| TCDD | 100 |
| 50 μM β-napthoflavone | 50 |
| 100 μM β-napthoflavone | 53 |
| Resveratrol | 12 |
| GTE | 10 |
| Apigenin | 1 |
| Naringenin | 0 |
| TCDD + resveratrol | 86 |
| TCDD +apigenin | 43 |
| TCDD + naringenin | 30 |
Each value represents the mean of two separate determinations that differed by <10%.
↵1-a CYP1A1 mRNA levels were normalized to TCDD induction (100% increase in CYP1A1 mRNA).