Table 2

The effect of flavonoids on CYP1A1 mRNA levels in primary cultures of human hepatocytes

TreatmentSubject
A2-aB2-aC2-bD2-a
%
TCDD100100N.D.100
Benzanthracene505010052
GTE340N.D.0
Resveratrol50120
ApigeninN.D.030
KaempferolN.D.0100
NaringeninN.D.N.D.N.D.0
TCDD +resveratrolN.D.N.D.N.D.51
TCDD +apigeninN.D.N.D.N.D.22
TCDD +naringeninN.D.N.D.N.D.20

  • N.D., not determined.

  • ↵2-a  CYP1A1 mRNA levels were normalized to TCDD induction (100% increase in CYP1A1 mRNA).

  • ↵2-b  CYP1A1 mRNA levels were normalized to benzanthracene induction (100% increase in CYP1A1 mRNA).