Metabolic activities toward chlorpyrifos in pooled male and female HLM
| Desulfuration | Dearylation | |||
|---|---|---|---|---|
| nmol/mg protein/min | nmol/nmol P450/min | nmol/mg protein/min | nmol/nmol P450/min | |
| Male | 0.24 ± 0.01 | 0.54 ± 0.01 | 0.47 ± 0.01 | 1.05 ± 0.03 |
| Female | 0.56 ± 0.02** | 0.89 ± 0.02** | 0.78 ± 0.02** | 1.23 ± 0.04* |
Activities are expressed as mean ± S.E.M. (n = 3 determinations), means in female HLM (pooled from 10 donors) significantly different than male HLM (pooled from 10 donors) are indicated by *p < 0.05 or**p < 0.01. Protein concentration and cytochrome P450 content in microsomes are provided by the supplier (XenoTech, LLC).