Table 1

Summary of predicted (in vitro) and observed (in vivo) clearance in rat

Compound	In Vivo Clearance	In Vitro Clearance
Compound	In Vivo Clearance	Fresh	Sandwich-cultured	Cryopreserved
	ml/min/kg	μl/min/million cells
1	48	6.4	12	3.4
2	34	4.1	3.6	0.45
3	30	6.9	3.1	1.4
4	8.5	9.3	15	4.2
5	3.9	1.3	4.9	0.43
6	13	3.7	6.4	0.37
7	7.3	2.5	5.1	0
8	16	7.6	8.7	2.7
9	13	2.3	3.2	2.3
10	35	11	11	3.6
11	100	30	37	8.7
12	3.9	8.5	7.2	0.97
13	12	12	9.9	3.6
14	4.4	8.7	7.3	0.59
15	8.6	7.4	3.8	0.54
16	7.2	5.3	5.3	1.4
17	61	22	25	14
18	88	25	26	12
19	23	14	14	3.4
20	0.45	0.3	1.2	0.0
21	29	13	12	3.7
22	19	2.0	2.6	0.0
23	36	16	22	6.3
24	32	10	6.8	2.4
25	8.2	3.0	4.4	0.8
26	7.0	3.3	3.5	1.6
27	16	7.0	7.9	3.3