Summary of predicted (in vitro) and observed (in vivo) clearance in dog
| Compound | In Vivo Clearance | In Vitro Clearance | ||
|---|---|---|---|---|
| Fresh | Sandwich-cultured | Cryopreserved | ||
| ml/min/kg | μl/min/million cells | |||
| 5 | 6.0 | 0.89 | 1.5 | 0.28 |
| 6 | 5.1 | 3.5 | 1.9 | 1.5 |
| 7 | 6.1 | 2.6 | 0.72 | 1.7 |
| 8 | 18 | 11 | 9.8 | 17 |
| 9 | 11 | 7.8 | 2.2 | 6.4 |
| 10 | 11 | 7.0 | 3.6 | 7.2 |
| 13 | 16 | 11 | 7.0 | 5.0 |
| 15 | 6.4 | 2.0 | 1.1 | 3.0 |
| 16 | 1.1 | 1.4 | 0.81 | 2.2 |
| 17 | 15 | 10 | 7.0 | 9.4 |
| 18 | 9.7 | 2.6 | 2.6 | 3.9 |
| 19 | 14 | 5.7 | 1.4 | 5.4 |
| 28 | 28 | 17 | 9.5 | 17 |
| 29 | 11 | 2.7 | 3.4 | 2.5 |
| 30 | 23 | 14 | 6.5 | 15 |
| 31 | 5.0 | 2.4 | 3.5 | 2.5 |
| 32 | 1.5 | 1.8 | 2.4 | 2.9 |
| 33 | 14 | 4 | 4.3 | 2.0 |