Table 5

Summary of predicted (in vitro) and observed (in vivo) clearance in human using cryopreserved hepatocytes

Compound	In Vivo Clearance	In Vitro Clearance	References
	ml/min/kg	μl/min/million cells
Tenoxicam	0.04	2.6	Heintz et al. (1984)
Warfarin	0.045	1.1	Benet et al. (1996)
Tolbutamide	0.24	1.6	Benet et al. (1996)
Diazepam	0.38	1.4	Benet et al. (1996)
Antipyrine	0.5	0.47	Schneider et al. (1999)
Furosemide	0.64	0.0	Hammarlund et al. (1984)
Theophylline	0.65	0.52	Benet et al. (1996)
Ibuprofen	0.75	4.2	Benet et al. (1996)
Terbutaline	1.0	0.0	Nyberg (1984)
Lorazepam	1.1	0.27	Benet et al. (1996)
Oxazepam	1.1	2.0	Benet et al. (1996)
Caffeine	1.4	1.4	Benet et al. (1996)
Sulpiride	1.5	0.0	Wiesel et al. (1980)
Sildenafil	6.0	5.2	Walker et al. (1999)
Midazolam	6.6	7.0	Benet et al. (1996)
Nifedipine	7.0	7.7	Benet et al. (1996)
Methylprednisolone	7.5	9.7	Al-Habet and Rogers (1989)
Imipramine	8.0	8.2	Ciraulo et al. (1988)
Chlorpromazine	8.6	11	Benet et al. (1996)
Prednisolone	8.7	9.7	Benet et al. (1996)
Desipramine	10.3	11	Ciraulo et al. (1988)
Diltiazem	12	4.7	Benet et al. (1996)
Chlorprothixene	12^5-a	14	Bagli et al. (1996)
Propranolol	13	10	Schneider et al. (1999)
Verapamil	14	16	Eichelbaum et al. (1984)
Naloxone	22	28	Benet et al. (1996)