Table 1

Effects of multiple oral dosing of KTZ (200mg b.i.d.) on pharmacokinetic parameters of MDZ (0.5mg/kg) after intravenous administrations to beagle dogs

Day	0	1	30
t _1/2β(h)	0.558 ± 0.118	1.20 ± 0.56^1-150	2.10 ± 0.43^1-150
CL_tot(ml/min/kg)	35.2 ± 2.8	20.9 ± 9.4^1-150	10.2 ± 4.5^1-150 ^1-152
Vd_ss (l/kg)	1.07 ± 0.17	1.25 ± 0.57	1.27 ± 0.34

Values are represented as the mean ± S.D. (n = 4). Day 0 represents pharmacokinetic parameters after intravenous MDZ administration before KTZ treatment.

↵1-150 Significant differences between the parameters on day 0 and the others by the paired Student's t test (p < 0.05).
↵1-152 Significant differences between the parameters on day 1 and 30 by the paired Student's t test (p < 0.05).