Metabolic pathway | R |
---|---|
1′-OH | 0.020–0.091 |
4-OH | 0.085–0.32 |
Total3-a | 0.025–0.11 |
R represents the ratio of calculated intrinsic clearance with KTZ (day 30) to that without KTZ (day 0). The values were calculated using eq. 6, as described in Experimental Procedures.
↵3-a Sum of intrinsic clearance for both pathways.