Table 2

Ring methyl oxidation and N-deethylation activities toward DEET in human cytochrome P450 isoforms expressed in baculovirus-infected insect cells

BALC (Ring Methyl Oxidation)ET (N-Deethylation)
nmol/nmol isoform/min
1A268.94  ± 2.64a Not detected
2B669.51  ± 1.83a Not detected
2D6*156.56  ± 2.52b Not detected
2E13.34  ± 0.17c Not detected
2A6Not detected4.55  ± 0.30a
2C19Not detected8.96  ± 0.82b
3A4Not detected5.05  ± 0.20a
3A5Not detected5.81  ± 0.24a

Means in the same column followed by the same letter are not significantly different (P < 0.01). Values are the mean ± S.E.M. (n = 3).