P450 inhibition by clotrimazole and its analogs in microsomes from human lymphoblast cells
| Ki Values | ||||
|---|---|---|---|---|
| P450 | Clotrimazole | Miconazole | Sulconazole | Tioconazole |
| μM | ||||
| 1A2 | 7.9 | 3.2 | 0.40 | 0.40 |
| 2A6 | 2.7 | 2.2 | 2.0 | 1.7 |
| 2B6 | 12.0 | 0.050 | 0.040 | 0.10 |
| 2C9 | 12.0 | 1.2 | 0.010 | 0.70 |
| 2C19 | 1.4 | 0.010 | 0.008 | 0.040 |
| 2D6 | 13.0 | 0.70 | 0.40 | 1.0 |
| 2E1 | 67.0 | 7.3 | 3.5 | 0.38 |
| 3A4 | 0.018 | 0.028 | 0.10 | 0.02 |