Table 3

Enzyme kinetic analyses of the formation of N-desmethylatomoxetine by human liver microsomes

Microsomal SampleKMVmaxCLint (Vmax/KM)
μM pmol/min/mg μl/min/mg
HLC91  ± 43-a 68  ± 10.75
HLM45  ± 836  ± 20.80
HLK3-b 113  ± 1197  ± 50.86
  • 3-a  Parameter estimate ± standard error of the parameter estimate.

  • 3-b  Human liver deficient in CYP2D6.