Tissues/Fluids | 14C | Brimonidine | ||||
---|---|---|---|---|---|---|
Tmax | Cmax | AUC | Tmax | Cmax | AUC | |
h | μg-Eq/g | μg-Eg · day/g | h | μg/g | μg · day/g | |
Tear | 1.0 | 24.8 | 138.0 | 1.0 | 22.70 | N.C. |
Lower bulbar conjunctiva | 1.0 | 56.2 | 542.0 | 1.0 | 53.50 | 438.0 |
Upper bulbar conjunctiva | 1.0 | 29.1 | 438.0 | 1.0 | 26.80 | 217.0 |
Cornea | 1.0 | 9.82 | 97.3 | 1.0 | 9.11 | 43.8 |
Lower sclera | 24.0 | 21.4 | 439.0 | N.A. | N.A. | N.A. |
Upper sclera | 1.0 | 20.1 | 255.0 | N.A. | N.A. | N.A. |
Aqueous humor | 1.0 | 0.327 | 3.13 | 1.0 | 0.270 | N.C. |
Iris | 24.0 | 610.0 | 10659.0 | 24.0 | 589.0 | 10378.0 |
Ciliary body | 24.0 | 32.8 | 1341.0 | 24.0 | 32.0 | 1237.0 |
Lens | 1.0 | 0.673 | 13.8 | N.A. | N.A. | N.A. |
Vitreous humor | 1.0 | 0.071 | 0.96 | N.A. | N.A. | N.A. |
Choroid/retina | 24.0 | 30.600 | 1499.0 | N.A. | N.A. | N.A. |
Blood | 15 days | 0.013 | 0.46 | N.A. | N.A. | N.A. |
Plasma | 1.0 | 0.012 | 0.04 | 1.0 | 0.003 | N.A. |
Terminal half-lives of radioactivity, determined between 15 and 90 days, were 33.3 days for iris and 44.2 days for vitreous humor. AUC was estimated over 90 days.
N.C., not calculable; N.A., not analyzed.