Substrate | Pathway | Enzyme Source | Reference |
---|---|---|---|
Benzyloxyresorufin | Resorufin formation | Baculovirus-expressed CYP3A4 | Lin et al., 2001 |
Celecoxib | Hydroxylation | Baculovirus-expressed CYP2C9 | Lin et al., 2001 |
Celecoxib | Hydroxylation | HLM | Tang et al., 2000 |
Dextromethorphan | O-Demethylation | Baculovirus-expressed CYP2D6 | Lin et al., 2001 |
Ethoxyresorufin | Resorufin formation | Baculovirus-expressed CYP1A2 | Lin et al., 2001 |
Fluoxetine | Demethylation | HLM | Stevens and Wrighton, 1993 |
Fluoxetine | Demethylation | HLM | Ring et al., 2001 |
Halothane | TFA formation3-a | cDNA-expressed CYP2E13-a | Spracklin et al., 1997 |
Halothane | Bromide formation | cDNA-expressed CYP2E13-a | Ibid. |
Progesterone | 6β-Hydroxylation | Baculovirus-expressed CYP3A4 | Lin et al., 2001 |
Tenoxicam | 5′-Hydroxylation | HLM | Zhao et al., 1992 |
Testosterone | 6β-Hydroxylation | Baculovirus-expressed CYP3A4 | Lin et al., 2001 |
Triazolam | 1′-Hydroxylation | HLM | Schrag and Wienkers, 2001 |
HLM, human liver microsomes; TFA, trifluoroacetic acid.
↵3-a Obtained from GENTEST.