Table 2

Summary of the biotransformation reactions catalyzed by recombinant human PYSO proteins

TaxoidsMetaboliteCYP2C8CYP3A4CYP3A5Other
PaclitaxelC6 +++
3′-Phenyl ++
DeacetylpaclitaxelC6 +++
2-Benzoyl + ++(3A7)
AcetyldocetaxelC6 +
3′-Phenyl ++
t-Butyl ++
Docetaxel t-Butyl +++ +
Baccatin IIIN.D. +
Deacetylbaccatin IIIN.D. + + (3A7)
  • N.D., not determined.