Table 4

Summary of the kinetic profiles observed for each of the model CYP2C9 substrates with respect to metabolism by CYP2C9*1 (wild-type enzyme), the polymorphic variants, and a man-made mutant CYP2C9 F114L involving active site amino acid changes

FlurbiprofenNaproxenPiroxicam
CYP2C9*1HyperbolicBiphasicSubstrate inhibition
CYP2C9*3HyperbolicLinearSubstrate inhibition
CYP2C9*5HyperbolicLinearHyperbolic
CYP2C9 F114LHyperbolicLinearSubstrate inhibition