Table 2

Glucuronidation of BaP metabolites by aerodigestive tract tissue and lung microsomes

9-OH-BaP2-a7-OH-BaP2-b3-OH-BaP2-aBaP-7,8-dihydrodiol2-b
nmol · mg protein−1 · 120 min−1
FoM2.04.52.6N.D.2-c
Tongue0.742.61.6N.D.2-c
Tonsil0.200.770.28N.D.2-d
Larynx5.37.23.90.032
Esophagus8.416.410.00.017
LungN.D.2-d N.D.2-d N.D.2-d N.D.2-d

All assays performed at 37°C for 2 h.

  • FoM, floor of mouth.

  • 2-a  Rate of glucuronidation calculated based upon one experiment.

  • 2-b  Rate of glucuronidation represented was the average of two independent experiments.

  • 2-c  N.D., not detectable in assays using 0.1 mg of microsomal protein.

  • 2-d  N.D., not detectable in assays using 1 mg of microsomal protein.