Table 1

Total amounts (ng/kg b.wt.) of ivermectin eliminated into bile and in the small intestinal lumen over 90 min postadministration in rat, and biliary and intestinal clearances

Dose (μg/kg)
100200400
Bile (ng/kg)170 ± 71a 389 ± 111b 667 ± 152c
Biliary clearance (ml/day/kg)55.7
Small intestine (ng/kg)862 ± 368a 1936 ± 204b 3526 ± 669c
Intestinal clearance (ml/day/kg)277.2
 Duodenum (ng/kg)146 ± 34a 338 ± 124b 511 ± 161b
 Jejunum (ng/kg)578 ± 318a 1320 ± 134b 2239 ± 541b
 Ileum (ng/kg)138 ± 32a 277 ± 62b 776 ± 172c
Ratiosmall intestine/bile 5.2 ± 1.5a 5.4 ± 1.8a 5.5 ± 2.0a

Ivermectin was administered intra-arterially at the doses of 100 (n = 6), 200 (n = 5), and 400 μg/kg b.wt. ivermectin (n = 5). The data are presented as means ± S.D. Comparisons were performed between the dose levels for each parameter. Values followed by the same superscript (ab orc) are not statistically different (p> 0.05).