Table 1

Total amounts (ng/kg b.wt.) of ivermectin eliminated into bile and in the small intestinal lumen over 90 min postadministration in rat, and biliary and intestinal clearances

	Dose (μg/kg)
	100	200	400
Bile (ng/kg)	170 ± 71^a	389 ± 111^b	667 ± 152^c
Biliary clearance (ml/day/kg)		55.7
Small intestine (ng/kg)	862 ± 368^a	1936 ± 204^b	3526 ± 669^c
Intestinal clearance (ml/day/kg)		277.2
Duodenum (ng/kg)	146 ± 34^a	338 ± 124^b	511 ± 161^b
Jejunum (ng/kg)	578 ± 318^a	1320 ± 134^b	2239 ± 541^b
Ileum (ng/kg)	138 ± 32^a	277 ± 62^b	776 ± 172^c
Ratio_{small intestine/bile}	5.2 ± 1.5^a	5.4 ± 1.8^a	5.5 ± 2.0^a

Ivermectin was administered intra-arterially at the doses of 100 (n = 6), 200 (n = 5), and 400 μg/kg b.wt. ivermectin (n = 5). The data are presented as means ± S.D. Comparisons were performed between the dose levels for each parameter. Values followed by the same superscript (^a^b or^c) are not statistically different (p> 0.05).