Examples of drugs that demonstrate supraproportional dose-exposure relationships in humans proposed to be due to saturation of metabolism
Drug | Indication | Reference |
---|---|---|
Cyclophosphamide | Anticancer | Chen, et al., 1997 |
5-Fluorouracil | Anticancer | Hidalgo, et al., 2000 |
Fluoxetine | Antidepressant | Lane, et al., 1995 |
Fluvoxamine | Antidepressant | Spigset, et al., 1998 |
Hydralazine | Antihypertensive | Shepherd, et al., 1984 |
Indinavir | Antiviral | Yeh, et al., 1999 |
Methylenedioxymethamphetamine | Drug of abuse | de la Torre, et al., 2000 |
Nefazodone | Antidepressant | Kaul, et al., 1995 |
Paroxetine | Antidepressant | Sindrup, et al., 1992 |
Propafenone | Antiarrhythmic | Siddoway, et al., 1987 |
Propranolol | β-Blocker | Silber, et al., 1983 |
Theophylline | Antiasthma | Tang-Liu, et al., 1982 |
Thiopental | Anaesthetic | Russo, et al., 1996 |
Thioridazine | Antipsychotic | Chakraborty, et al., 1989 |