Examples of drugs that demonstrate supraproportional dose-exposure relationships in humans proposed to be due to saturation of metabolism
| Drug | Indication | Reference |
|---|---|---|
| Cyclophosphamide | Anticancer | Chen, et al., 1997 |
| 5-Fluorouracil | Anticancer | Hidalgo, et al., 2000 |
| Fluoxetine | Antidepressant | Lane, et al., 1995 |
| Fluvoxamine | Antidepressant | Spigset, et al., 1998 |
| Hydralazine | Antihypertensive | Shepherd, et al., 1984 |
| Indinavir | Antiviral | Yeh, et al., 1999 |
| Methylenedioxymethamphetamine | Drug of abuse | de la Torre, et al., 2000 |
| Nefazodone | Antidepressant | Kaul, et al., 1995 |
| Paroxetine | Antidepressant | Sindrup, et al., 1992 |
| Propafenone | Antiarrhythmic | Siddoway, et al., 1987 |
| Propranolol | β-Blocker | Silber, et al., 1983 |
| Theophylline | Antiasthma | Tang-Liu, et al., 1982 |
| Thiopental | Anaesthetic | Russo, et al., 1996 |
| Thioridazine | Antipsychotic | Chakraborty, et al., 1989 |