Substrate | Enzyme Source | Model | KM orS50 | Vmax5-a | Hill Coefficient |
---|---|---|---|---|---|
(n)5-b | |||||
BFC | HLM (0–2.5 μM) | Hyperbola | 3.8 ± 0.6 | 250 ± 27 | — |
BFC | HLM (5–160 μM) | Hill | 23 ± 2 | 1325 ± 51 | 1.4 ± 0.1 |
BFC | CYP3A4 | Hill | 40 ± 2.5 | 58 ± 1.7 | 1.3 ± 0.1 |
BFC | CYP3A5 | Hill | 33 ± 1.0 | 3.1 ± 0.1 | 1.5 ± 0.1 |
BFC | CYP1A2 | Hyperbola | 18 ± 0.3 | 6.1 ± 0.05 | — |
BFC | CYP2C19 | Hyperbola | 26 ± 2 | 0.53 ± 0.01 | — |
BQ | HLM (0–320 μM) | Hyperbola/ | S 50 = 70 ± 2.5 | V 1 4892 ± 1929 | 2.7 ± 0.7 |
Hill (eq. 1) | K M = 28 ± 45 | V 2 1714 ± 2195 | — | ||
BQ | HLM (0–5 μM) | Hyperbola | 6.7 ± 22 | 539 ± 1151 | — |
BQ | HLM (10–320 μM) | Hill | 62 ± 4 | 6807 ± 231 | 1.8 ± 0.2 |
BQ | CYP3A4 | Hill | 22 ± 0.82 | 26 ± 0.48 | 1.9 ± 0.1 |
BQ | CYP3A5 | Hill | 52 ± 1.8 | 10 ± 0.2 | 1.5 ± 0.1 |
BQ | CYP1A2 | Hyperbola | 53 ± 5.5 | 4.4 ± 0.15 | — |
AMMC | RLM | Hyperbola | 7.4 ± 0.4 | 1440 ± 24 | — |
AMMC | CYP2D2 | Hyperbola | 4.6 ± 1.6 | 24 ± 2.9 | — |