Table 6

Correlation coefficients for dealkylation of the fluorometric probe and P450 isoform selective catalytic activities in a panel of human donors

Human P450 Isoform	Correlation Coefficient
Human P450 Isoform	Catalytic Activity	BFC	BFC ⁺ 0.5 μM Ketoconazole	BQ	AMMC 1.5 μM	AMMC 25 μM	AMMC 25 μM ⁺0.5 μM Quinidine
CYP1A2	PhenacetinO-Deethylase	0.00	0.87^6-160	−0.08	0.06	0.16	0.45
CYP2A6	Coumarin 7-hydroxylase	0.14	−0.15	0.33	0.17	0.09	0.10
CYP2B6	(S)-Mephenytoin N-demethylase	0.88^6-160	0.03	0.86^6-160	−0.31	−0.19	−0.19
CYP2C8	Paclitaxel 6α-hydroxylase	0.58	0.21	0.58^6-150	−0.24	−0.08	0.13
CYP2C9	Diclofenac 4′-hydroxylase	0.37	0.50	0.29	−0.15	−0.03	0.16
CYP2C19	(S)-Mephenytoin 4′-hydroxylase	0.29	0.37	0.25	−0.31	−0.41	−0.27
CYP2D6	Bufuralol 1′-hydroxylase	−0.33	−0.11	−0.19	0.93^6-160	0.72^6-160	0.41
CYP2E1	Chlorzoxazone 6-hydroxylase	0.26	0.34	0.21	0.22	−0.05	−0.24
CYP3A4	Testosterone 6β-hydroxylase	0.95^6-160	0.08	0.97^6-160	−0.48	−0.47	−0.46
CYP4A11	Lauric acid 12-hydroxylase	−0.22	0.46	−0.13	0.39	0.27	0.38
	Total P450 (pmol/mg)	0.75^6-160	0.63^6-150	0.68^6-150	−0.21	−0.16	0.05

↵6-150 P < 0.05,
↵6-160 P < 0.01.