Correlation of ketamine N-demethylase activity with P450 isoform-specific activities in seven human liver microsomes
| Isoform-specific Activities | Spearman Correlation Coefficient (r) |
|---|---|
| Nifedipine oxidase activity (CYP3A4) | 0.8991-150 |
| Coumarin 7-hydroxylase activity (CYP2A6) | 0.725 |
| Phenacetin deethylase activity (CYP1A2) | 0.551 |
| S-Mephenytoin hydroxylase activity (CYP2C19) | 0.4 |
| Dextromethorphan demethylase activity (CYP2D6) | −0.3 |
| Chlorzoxazone hydroxylase activity (CYP2E1) | 0.371 |
| S-Mephenytoin N-demethylase activity (CYP2B6) | 0.8861-150 |
| Tolbutamide hydroxylase activity (CYP2C9) | 0.029 |
↵1-150 p < 0.05.