Parameters | Allometric Coefficients | Allometric Exponents | Correlation Coefficients | Human Value | ||
---|---|---|---|---|---|---|
Predicted | Observed a | |||||
MRT (h) | 3.56 | 0.303 | 0.826 | 13.5 | — b | |
Vss (l) | 1.16 | 0.942 | 0.986 | 73.0 | 71 | |
Vss/f (l) | 5.82 | 0.974 | 0.999 | 419 | 284 c | |
CLr (ml/min) | 1.24 | 0.608 | 0.953 | 17.9 | — b | |
CLr/f (ml/min) | 6.22 | 0.639 | 0.931 | 103 | — b | |
CLer (ml/min) | 4.40 | 0.598 | 0.963 | 61 | — b | |
CLer/f (ml/min) | 22.1 | 0.629 | 0.904 | 350 | — b | |
CL (ml/min) | 5.84 | 0.607 | 0.991 | 84.1 | 86.1 d | |
CL · MLP (ml/min) | 59.3 | 0.985 | 0.995 | 48.3 | 86.1 d | |
CL · BW (ml/min) | 74.0 | 1.61 | 0.981 | 63.1 | 86.1 d | |
CL · UGT (ml/min) | 22.3 | 0.913 | 0.979 | 390 | 86.1 d | |
CL · Q (ml/min) | 0.0640 | 1.06 | 0.898 | 77.5 | 86.1 d | |
CL · UGT · Q (ml/min) | 0.244 | 1.37 | 0.936 | 359 | 86.1 d | |
CL/f (ml/min) | 29.3 | 0.638 | 0.933 | 483 | 344 c | |
CL/f · MLP (ml/min) | 297 | 1.02 | 0.978 | 277 | 344 c | |
CL/f · BW (ml/min) | 371 | 1.64 | 0.978 | 362 | 344 c | |
CL/f · UGT (ml/min) | 112 | 0.944 | 0.931 | 2241 | 344 c | |
CL/f · Q (ml/min) | 0.320 | 1.09 | 0.858 | 445 | 344 c | |
CL/f · UGT · Q (ml/min) | 1.22 | 1.40 | 0.899 | 2065 | 344 c |
↵ a The human data were obtained from a presentation at the 41st ICCAC (Gajjar et al, 2001).
↵ b The results were not obtained.
↵ c Estimated from the free fraction in human serum of 0.25 (Bello et al., 2001).
↵ d The CL was calculated from the value of the AUC (77.4 μg · h/ml) after intravenous 400-mg dose (Gajjar et al, 2001).