Metabolic profiles of garenoxacin in the plasma and excreta of dogs
Metabolic profiles were determined in samples pooled from three animals following intravenous administration of 14C-garenoxacin at 100 mg/kg. Results are expressed as percentage of radioactivity in samples. Amounts excreted into the urine and feces were expressed as percentage of dose (mean ± S.D.).
Sample | Amount (% Dose) | Metabolites (Percentage of Sample Radioactivity) | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| GRX | M1 | M2 | M3 | M4 | M5 | M6 | UN 2 m | |||||||||
| Plasma 5 min | N.A. | 100 | N.D. | N.D. | N.D. | N.D. | N.D. | N.D. | N.D. | |||||||
| Plasma 2 h | N.A. | 91.8 | 8.2 | N.D. | N.D. | N.D. | N.D. | N.D. | N.D. | |||||||
| Plasma 6 h | N.A. | 90.9 | 9.1 | N.D. | N.D. | N.D. | N.D. | N.D. | N.D. | |||||||
| Plasma 24 h | N.A. | 100 | N.D. | N.D. | N.D. | N.D. | N.D. | N.D. | N.D. | |||||||
| Urine 0-24 h | 30.0 ± 2.7 | 88.3 | 4.6 | 0.8 | N.D. | N.D. | N.D. | 2.1 | 4.2 | |||||||
| Feces 0-24 h | 30.7 ± 8.1 | 70.4 | 18.5 | 1.5 | 3.1 | N.D. | N.D. | 1.9 | 4.5 | |||||||
Amount, excretion of radioactivity as percentage of dose; GRX, garenoxacin; M1, T-3811M1; M2, carbamoyl glucuronide; M3, carbamic acid; M4, T-3811M4; M5, T-3811M5; UN 2 m, unknown metabolite at retention time 2 min; N.D., not detected; N.A., not applicable.