Plasma pharmacokinetic parameter estimates for ISIS 104838 after i.v. administration in monkey and compared across dose
Standard deviation of individual estimates (n = 3-6) are represented in parentheses.
Parameter | i.v. Bolus (mg/kg) | i.v. 1-h Infusion (mg/kg) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0.125 | 0.5 | 1 | 2 | 1 | 3 | 10 | ||||||
| Co (μg/ml) | 2.5 (0.3) | 8.9 (1.6) | 18.6 (1.9) | 36.1 (6.3) | ||||||||
| Cmax (μg/ml) | 7.93 (1.17) | 32.6 (4.35) | 91.9 (14.7) | |||||||||
| AUC (μg · h/ml) | 0.49 (0.12) | 2.98 (0.50) | 7.27 (0.29) | 20.7 (1.4) | 7.87 (1.43) | 45.5 (10.0) | 149 (25.7) | |||||
| CL (ml/h/kg) | 266 (76.2) | 172 (30.6) | 138 (5.4) | 97.1 (6.4) | 131 (24.0) | 68.4 (15.0) | 69.0 (11.8) | |||||
| Vss (ml/kg) | 56.5 (1.9) | 63.6 (12.1) | 49.7 (1.7) | 57.3 (7.3) | 94.7 (16.7) | 65.2 (9.4) | 106 (28.9) | |||||
| t½k10 (h) | 0.17 (0.04) | 0.33 (0.09) | 0.23 (0.03) | 0.37 (0.03) | 0.34 (0.07) | 0.55 (0.08) | 0.79 (0.07) | |||||
Co, plasma concentration at time 0, immediately after i.v. bolus injection.