Table 2

Correlation of UGT1A6 protein content with UGT activities

UGT1A6 Protein Content Versus
RsPn
Serotonin-UGT (4 mM)0.769<0.00152
Serotonin-UGT (40 mM)0.721<0.00152
4-Nitrophenol-UGT0.756<0.00151
Estradiol-3-UGT0.537<0.00151
Trifluoperazine-UGT0.638<0.00151
Propofol-UGT0.433<0.00151
Acetaminophen-UGT0.2280.25926
AZT-UGT−0.2400.19131
Morphine-3-UGT0.0110.94931
S-Oxazepam-UGT−0.0800.65333
R-Oxazepam-UGT0.0090.95933

Different glucuronidation activities and immunoquantified UGT1A6 protein content were measured for the same set of human liver microsomes and compared by correlation analysis using UGT1A6 protein content as the dependent variable. Serotonin-UGT activity was measured at 4 and 40 mM aglycone concentrations. Values represent theRs, P value, and number of livers (n) for the indicated comparisons.