Segmental distribution of transporters and enzymes among the intestinal segments
Transporter | Segmental Distribution | References |
|---|---|---|
| Asbt | distal intestine > proximal intestine | Schneider et al., 1995; Aldini et al., 1996 |
| Pept1 | proximal intestine > distal ileum function: (jejunum > ileum > duodenum) | Fei et al., 1994 |
| Mct1 | duodenum < jejunum > ileum | Tamai et al., 1999; Cong et al., 2001 |
| Oatp3 | highest in jejunum | Walters et al., 2000 |
| CNT | highest in jejunum | Ngo et al., 2001 |
| CYP3A | duodenum ∼ jejunum > ileum | Paine et al., 1996, 1997; Li et al., 2002 |
| UGT | duodenum ∼ jejunum > ileum | Koster et al., 1985 |
| PST | duodenum ∼ jejunum > ileum | Schwartz and Schwenk, 1974 |
| GST | duodenum ∼ jejunum > ileum | Pinkus et al., 1977 |
| Estrone sulfatase | proximal > distal | Huijghebaer et al., 1984 |
| Mrp2 | duodenum ∼ jejunum > ileum | Mottino et al., 2000; Gotoh et al., 2000 |
| Mdr1 | jejunum ∼ ileum > duodenum | Saitoh and Aungst, 1995; Collett et al., 1999; Li et al., 2002 |
| Mrp3 (basolateral) | ileum > jejunum > duodenum |
Rost et al., 2002
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