Table 2

The ratio of parent drug to metabolite

	AUC_PARENT	AUC_BE	Ratio
	ng/ml × h	ng/ml × h	BE/parent
Cocaine alone	58783 ± 11282	118336 ± 35222	1.98 ± 0.23
Cocaine ⁺EtOH	74741 ± 13641	106024 ± 28199	1.42 ± 0.28^2-a
CE alone	52924 ± 5764	103217 ± 27904	1.94 ± 0.42
CE ⁺EtOH	71400 ± 17160	97802 ± 8013	1.42 ± 0.30^2-b

The area under the curve from 0 to 300 min estimated using the trapezoidal rule for cocaine, cocaethylene, and benzoylecgonine. The AUCs for cocaine (3 mg/kg) and cocaethylene (2.6 mg/kg) are similar as are their respective benzoylecgonine metabolite AUCs. The change in benzoylecgonine metabolite AUCs with the coadministration of ethanol are identical as demonstrated by equal changes in the benzoylecgonine to parent AUC ratio.

↵2-a Different from cocaine alone,p < 0.05.
↵2-b Different from cocaethylene (CE) alone, p < 0.05.