Irreversibility of the inactivation of P450 2B6 by PCP
| Sample | % Activity Remaining | |
|---|---|---|
| Control2-a | Inactivated | |
| Before dialysis | 100 | 34 ± 14 |
| After dialysis | 100 | 34 ± 3 |
| After dialysis + fresh reductase | 100 | 49 ± 2 |
P450 2B6 was inactivated by PCP, dialyzed overnight, and assayed for activity as described in Materials and Methods. Each value represents the mean and S.D. of four experiments.
↵2-a For comparison purposes, the values obtained for the control samples in each case were designated to represent 100% activity.