Substrate metabolism by rat liver microsomes
| Rat Liver Microsomes | Clopidogrel Oxidation | 7-Ethoxyresorufin Deethylation | 6β-Testosterone Hydroxylation | Erythromycin Demethylation |
|---|---|---|---|---|
| nmol product min−1 nmol P450 −1 1-a | ||||
| Control | 2.3 ± 0.1 | 0.112 ± 0.020 | 0.9 ± 0.1 | 4.8 ± 0.2 |
| Dexamethasome | 3.9 ± 0.5 | 0.043 ± 0.003 | 4.2 ± 0.2 | 5.6 ± 0.1 |
| β-napthoflavone | 0.2 ± 0.2 | 0.332 ± 0.025 | 0.2 ± 0.03 | 1.8 ± 0.2 |
↵1-a Assays were performed as described under Experimental Procedures. Values represent the mean ± S.D. of three determinations.