Excretion of radioactivity following a single oral dose of14C-atomoxetine administered to Fischer 344 rats and bile duct cannulated Fischer 344 rats
| Percentage of Radioactive Dose Excreted | ||||
|---|---|---|---|---|
| Urine | Feces | Bile | Total | |
| Intact Fischer 344 rat | ||||
| 0–6 h | 5.7 ± 1.0 | 5.7 ± 1.0 | ||
| 6–12 h | 14.5 ± 2.0 | 14.5 ± 2.0 | ||
| 12–24 h | 33.3 ± 1.3 | 20.7 ± 4.63-a | 54.0 ± 5.8 | |
| 24–48 h | 12.3 ± 3.0 | 8.5 ± 1.7 | 20.9 ± 4.6 | |
| Excreta total | 65.9 ± 3.1 | 29.3 ± 2.9 | 97.2 ± 0.93-b | |
| Cannulated Fischer 344 rat | ||||
| 0–8 h | 7.3 ± 3.1 | 23.7 ± 9.3 | 31.0 ± 8.8 | |
| 8–16 h | 8.9 ± 4.0 | 5.8 ± 2.3 | 14.7 ± 2.2 | |
| 16–24 h | 4.0 ± 1.9 | 0.27 ± 0.123-a | 6.8 ± 2.5 | 10.7 ± 1.4 |
| 24–48 h | 14.7 ± 4.7 | 2.2 ± 1.2 | 12.8 ± 6.3 | 29.7 ± 6.0 |
| Excreta total | 34.8 ± 11.2 | 2.5 ± 1.1 | 49.1 ± 16.2 | 98.9 ± 2.93-b |
Data represents means + S.E.M. (n = 3 or 4 animals). Rats received a 50 mg/kg (50 μCi/kg) dose.
↵3-a Represents radioactivity collected in feces from 0 to 24 h.
↵3-b Total includes radioactivity recovered in urine and feces, as well as the carcass (2.1 ± 0.3% and 12.5 ± 3.6% of the dose was recovered from the carcass for Fischer 344 rats and bile duct cannulated Fischer 344 rats, respectively).