Table 3

Quantitation of etoricoxib metabolites as the percent of total radioactivity in human urine (0–24 hr) following i.v. (25 mg) and p.o. (100 mg) administration of [¹⁴C]etoricoxib

Subject Number	Dose Route	Percent of Total Radioactivity Excreted in Urine (0–24 hr) as Etoricoxib and Its Metabolites^3-a ^3-b
Subject Number	Dose Route	6′-Carboxy-etoricoxib	6′-Hydroxy-methyl-etoricoxib Glucuronide	6′-Hydroxy-methyl-etoricoxib-1′-N-oxide	Etoricoxib-1′-N-oxide	6′-Hydroxy-methyl-etoricoxib	Etoricoxib
Mean	i.v.	78.1	6.78	1.91	4.20	2.65	0.81
S.D.		3.85	1.38	0.64	1.78	1.00	0.58
		(27.2)	(2.40)	(0.70)	(1.50)	(0.90)	(0.30)
Mean	p.o.	79.7	5.99	1.70	4.04	2.48	0.90
S.D.		5.29	1.78	0.66	2.39	1.29	0.81
		(26.5)	(2.00)	(0.60)	(1.30)	(0.80)	(0.30)

↵3-a Data represent mean and S.D. of n = 6 subjects. The data in parentheses represent the mean percent of the dose recovered in urine as unchanged etoricoxib and each of its metabolites (percent of dose in 0–24 h urine was 34.9 and 33.3% after the i.v. and p.o. dose, respectively).
↵3-b The total amount of radioactivity accounted for as parent and metabolites in 0–24 h urine after i.v. and p.o. dosing is 95%.