Subject Number | Dose Route | Percent of Total Radioactivity Excreted in Urine (0–24 hr) as Etoricoxib and Its Metabolites3-a3-b | |||||
---|---|---|---|---|---|---|---|
6′-Carboxy-etoricoxib | 6′-Hydroxy-methyl-etoricoxib Glucuronide | 6′-Hydroxy-methyl-etoricoxib-1′-N-oxide | Etoricoxib-1′-N-oxide | 6′-Hydroxy-methyl-etoricoxib | Etoricoxib | ||
Mean | i.v. | 78.1 | 6.78 | 1.91 | 4.20 | 2.65 | 0.81 |
S.D. | 3.85 | 1.38 | 0.64 | 1.78 | 1.00 | 0.58 | |
(27.2) | (2.40) | (0.70) | (1.50) | (0.90) | (0.30) | ||
Mean | p.o. | 79.7 | 5.99 | 1.70 | 4.04 | 2.48 | 0.90 |
S.D. | 5.29 | 1.78 | 0.66 | 2.39 | 1.29 | 0.81 | |
(26.5) | (2.00) | (0.60) | (1.30) | (0.80) | (0.30) |
↵3-a Data represent mean and S.D. of n = 6 subjects. The data in parentheses represent the mean percent of the dose recovered in urine as unchanged etoricoxib and each of its metabolites (percent of dose in 0–24 h urine was 34.9 and 33.3% after the i.v. and p.o. dose, respectively).
↵3-b The total amount of radioactivity accounted for as parent and metabolites in 0–24 h urine after i.v. and p.o. dosing is 95%.