Table 1

Effect of preincubation on apparent IC₅₀values for paroxetine, fluoxetine, and quinidine versus dextromethorphan O-demethylation in vitro

	IC₅₀Value
	Without Preincubation	With Preincubation
	μM
Paroxetine
Mean (±S.E.), n = 4	2.85 (±0.84)^*	0.36 (±0.05)^*
From mean data points	2.5	0.3
Fluoxetine
Mean (±S.E.),n = 4	0.24 (±0.02)	0.39 (±0.10)
From mean data points	0.21	0.42
Quinidine
Mean (±S.E.),n = 4	0.40 (±0.09)	0.48 (±0.17)
From mean data points	0.23	0.36

1-178 , p < 0.05 using Student's pairedt test on ranks.