Effect of preincubation on apparent IC50values for paroxetine, fluoxetine, and quinidine versus dextromethorphan O-demethylation in vitro
IC50Value | ||
---|---|---|
Without Preincubation | With Preincubation | |
μM | ||
Paroxetine | ||
Mean (±S.E.), n = 4 | 2.85 (±0.84)* | 0.36 (±0.05)* |
From mean data points | 2.5 | 0.3 |
Fluoxetine | ||
Mean (±S.E.),n = 4 | 0.24 (±0.02) | 0.39 (±0.10) |
From mean data points | 0.21 | 0.42 |
Quinidine | ||
Mean (±S.E.),n = 4 | 0.40 (±0.09) | 0.48 (±0.17) |
From mean data points | 0.23 | 0.36 |
1-178 , p < 0.05 using Student's pairedt test on ranks.