Table 1

Effect of preincubation on apparent IC50values for paroxetine, fluoxetine, and quinidine versus dextromethorphan O-demethylation in vitro

IC50Value
Without PreincubationWith Preincubation
μM
Paroxetine
 Mean (±S.E.), n = 42.85 (±0.84)* 0.36 (±0.05)*
 From mean data points2.50.3
Fluoxetine
 Mean (±S.E.),n = 40.24 (±0.02)0.39 (±0.10)
 From mean data points0.210.42
Quinidine
 Mean (±S.E.),n = 40.40 (±0.09)0.48 (±0.17)
 From mean data points0.230.36
  • 1-178 , p < 0.05 using Student's pairedt test on ranks.