Mean (S.D.) PK parameters of melagatran following intravenous administration of melagatran to rats, dogs, and humans
| Species and Dose | Gender | n | CL | Vss | t |
|---|---|---|---|---|---|
| ml/min/kg | l/kg | h | |||
| Rat | |||||
| 2 μmol/kg | M | 4 | 15.8 (2.1) | 0.37 (0.02) | 0.4 (0.03) |
| 2 μmol/kg | F | 4 | 18.0 (3.6) | 0.40 (0.10) | 0.4 (0.05) |
| Dog | |||||
| 2 μmol/kg | M/F | 4 | 7.0 (1.0) | 0.36 (0.04) | 1.2 (0.2) |
| Human5-a | |||||
| 2.3 mg (5.3 μmol) | M | 12 | 145 (15)5-b | 17.3 (1.7)5-c | 1.6 (0.2) |