Volume, flow, and other parameters for simulation of the area under the curves (AUC), metabolite formation (M), and bioavailability (F) of the intestine, which was viewed as three segments of each volume that received the proportional flow rate (no other clearance was assumed to exist, that is CLo = 0).
| Segmental Traditional Model STM | Segmental, Segregated Flow Model SSFM | |
|---|---|---|
| Compartment volumes (ml) | ||
| Reservoir,V R | 200 | 200 |
| Lumen,V lum (V lum1,V lum2,V lum3) | 2 (0.667) | 2 (0.667) |
| Parameters for STM | ||
| Intestinal blood volume,V int,b (V intb1,V intb2,V intb3) | 0.9 (0.3) | |
| Total intestinal tissue,V int (V int1,V int2,V int3) | 1.62 (0.54) | |
| Parameters for SSFM | ||
| Serosa and other tissues,V s (V s1,V s2,V s3) | 1.458 (0.486) | |
| Enterocyte membrane layer,V en (V en1,V en2,V en3) | 0.162 (0.054) | |
| Blood volume to serosal layer,V sb (V sb1,V sb2,V sb3) | 0.81 (0.27) | |
| Blood volume to enterocyte layer,V en,b (V mb1,V mb2,V mb3) | 0.09 (0.03) | |
| Flow Rate (ml/min) | ||
| Total intestinal flow,Q int | 8 | 8 |
| Flow to each intestinal segment, Q int,I | 2.67 | |
| Flow to enterocyte layer of segment, f Q Q int/31-a | 0.267 | |
| Flow to serosal layer of segment, (1 - f Q)Q int/31-b | 2.4 |