Calculation of Kiiv of fluvoxamine toward CYP2C19 for individual subjects (n = 12)
| Subject | Fluvoxamine Average Concentration | CLf,4-OH/CLfi,4-OH | Kiiv | ||||
|---|---|---|---|---|---|---|---|
| 37.5 mg/day | 62.5 mg/day | 87.5 mg/day | 37.5 mg/day | 62.5 mg/day | 87.5 mg/day | ||
| nM | nM | ||||||
| 1 | 44.0 | 71.3 | 149 | 3.75 | 4.65 | 8.51 | 20.2 |
| 2 | 41.8 | 83.4 | 96.0 | 5.53 | 9.76 | 10.9 | 9.7 |
| 3 | 25.9 | 68.8 | 77.2 | 2.79 | 3.52 | 4.49 | 25.8 |
| 4 | 35.3 | 42.9 | 53.8 | 2.91 | 3.87 | 4.65 | 14.9 |
| 5 | 17.2 | 44.7 | 66.6 | 2.06 | 4.18 | 4.88 | 16.5 |
| 6 | 15.8 | 56.2 | 75.4 | 1.37 | 4.47 | 5.93 | 14.7 |
| 7 | 20.8 | 37.8 | 59.4 | 3.69 | 5.61 | 7.37 | 9.3 |
| 8 | 11.8 | 46.9 | 104.8 | 2.69 | 4.65 | 12.0 | 9.8 |
| 9 | 32.3 | 57.7 | 138.0 | 2.84 | 6.05 | 9.66 | 15.8 |
| 10 | 28.7 | 62.4 | 156 | 3.70 | 6.13 | 17.4 | 9.4 |
| 11 | 122 | 201 | 272 | 16.1 | 23.8 | 33.2 | 8.6 |
| 12 | 61.4 | 151 | 249 | 13.7 | 18.1 | 38.6 | 7.3 |
| Mean | 38.1 | 77.0 | 125 | 5.10 | 7.90 | 13.1 | 13.5 |
| S.D. | 30.0 | 49.1 | 72.2 | 4.73 | 6.43 | 11.3 | 5.6 |