Physiological parameters for calculation of intrinsic clearance in rats and humans
| Rat | Human | |
|---|---|---|
| Number of hepatocytes/g liver (cells/g liver) | 120 × 106 | 120 × 106 |
| Liver weight/kg body weight (g liver/kg) | 40 | 25.7 |
| Liver blood flow (ml/min/kg) | 55.2 | 20.7 |
Data from Bayliss et al. (1999) and Davies and Morris (1993).