Binding of the model compounds to rat freshly isolated hepatocytes and their effects on the values of rat scaling factor
| Compounds | fu,hepatocytes | Rat CLuint,in vitro | Rat Scaling Factor | |
|---|---|---|---|---|
| Well Stirred | Dispersion | |||
| ml/min/kg | ||||
| FK1052 | 0.244 | 2600 | 10.7 | 3.1 |
| FK480 | 0.202 | 1120 | 5.1 | 3.4 |
| Diazepam | 0.705 | 489 | 1.6 | 1.0 |
| Diltiazem | 0.529 | 6240 | 0.3 | 0.1 |
| Quinotolast | 0.937 | 58.3 | 9.8 | 8.4 |
| Troglitazone | 0.217 | 4280 | 15.8 | 10.2 |
| FK079 | 0.713 | 6.66 | 4.3 | 4.2 |
| Zidovudine | 1.000 | 14.3 | 1.4 | 1.3 |
| Acetaminophen | 0.933 | 76.4 | 0.7 | 0.5 |