Apparent kinetic parameters for the N-oxidation of voriconazole in microsomes prepared from three individual human livers (determinations were n = 2 for each liver)
| Human Liver | High Affinity | Low Affinity | ||
|---|---|---|---|---|
| Km | Vmax | Km | Vmax | |
| μM | pmol/mg/min | μM | pmol/mg/min | |
| HM11 | 11.0 | 1.4 | 732.7 | 3.6 |
| HM18 | 5.2 | 4.4 | 1045.0 | 32.6 |
| HM22 | 8.0 | 22.0 | 726.3 | 60.3 |
| Mean ± S.D. | 8.1 ± 2.9 | 9.3 ± 11.1 | 834.7 ± 182.2 | 32.2 ± 28.4 |