Correlation of voriconazole N-oxidation and P450 activities (using log data for both) across a bank of human liver microsomes (determinations were n = 4 for each liver)
| P450 (Substrate) | 25 μM Voriconazole | 2500 μM Voriconazole |
|---|---|---|
| CYP1A2 (caffeine) | 0.59 | 0.48 |
| CYP2A6 (coumarin) | 0.53 | 0.65 |
| CYP2C9 (S-warfarin) | 0.53 | 0.43 |
| CYP2C19 (S-mephenytoin) | 0.77 | 0.47 |
| CYP2D6 (bufuralol) | 0.34 | 0.45 |
| CYP2E1 (p-nitrophenol) | 0.45 | 0.47 |
| CYP3A4 (testosterone) | 0.74 | 0.90 |